Institution Remuneration group Full-time / Part-time Start date Application deadline

Faculty of Physics – Experimental Physics TV-L E13
Part-time (66%)
as soon as possible ( limited to three years) 2024- 12- 31

About us:

The Chair of Experimental Physics – Medical Physics in the Faculty for Physics of the Ludwig- Maximilians-Universität München (LMU) aims to promote research and teaching in the eld of medical physics, with special focus on advances in pre-clinical and clinical radiotherapy for a wide range of beam modalities, from established conventional sources of photons and hadrons up to laser-based systems.

We are looking f or you:

PhD position for acoustic / ultrasonic imaging (m/f/x)

in Garching

Your tasks and responsibilities:

Particle therapy with protons and heavier ion beams is rapidly emerging as a promising radiation therapy modality due to the superior ability to concentrate energy deposition in the tumor, while better sparing normal tissue and critical organs compared to widely established photons. Despite considerable recent technological advances, full clinical exploitation of the favorable ballistic properties of ion beams is still hampered by the yet unsolved problem of range uncertainties in tissue. In this context, ionoacoustics has been identied over the last years as a promising modality to localize the maximum energy deposition (so- called Bragg peak) [1]. However, the strength and shape of the ionoacoustic signal crucially depend on the spatial distribution and temporal structure of the heating process, i.e., dose deposition. In clinical scenarios, this leads to weak pressures (up to some mPa) in the tenth of kHz frequency range [2], making the detection of the ionoacoustic waves a technological challenge. To overcome this challenge, our team proposed the use of contrast agents [3], aiming to enhance the ionoacoustic emissions and improve the co-registration with other imaging modalities (e.g., ultrasound or X-ray imaging). This will be the topic that the successful candidate will have the opportunity to investigate with our team in the framework of the recently granted DFG project “Contrast enHanced-IonoAcoustics in Proton and heavy Ion beam therapy” CHIAPI, see also.

As a part of the team, you will be actively involved in the assessment of novel contrast agents and the development of dedicated imaging strategies, including:

Simulation workow for in-silico assessment of the expected contrast agent performances in vivo in realistic clinical scenarios

• Reconstruction of the dose in patients from contrast-enhanced ionoacoustic signals
• Co-registration of ionoacoustics with patient anatomy from ultrasound morphological imaging and

  additional pre-treatment images (e.g., X-ray CT)

• Experimental demonstration and validation of the combined ionoacoustic/ultrasound imaging in a realistic phantom at clinical proton beamlines.

  Your qualications:

  ■ Master’s degree in physics or biomedical engineering
  ■ Fluent English knowledge (spoken and written)
  ■ A transdisciplinary research orientation with demonstrated research experience or interest ■ Ability to work independently and collaboratively in a team environment
  ■ Motivated and self-driven with a passion for scientic research and innovation.

  Assessment criteria and other qualications

  The candidates will be evaluated based on their qualications, suitability for the research topics, and potential as researchers. The following merits are seen as strong advantages:

• Solid background in programming (preferably Python and Fortran)
• Experience in Monte Carlo simulations in ion/proton therapy (preferably FLUKA code)
• Familiarity with photoacoustics and/or ionoacoustics with experience in thermoacoustic simulations (e.g., k-Wave toolbox)
• Practical experience with data acquisition and image reconstruction techniques
• Experience in carrying out research in international and multidisciplinary teams.

  Benets:

  We offer you an interesting and fullling job with good opportunities for further training and development. Your workplace is located at the Forschungszentrum Garching and is easily accessible by public transport. You will be paid in TV-L E13 66% according TV-L salary scale, depending on your professional qualications. This position is initially limited to three years with the possibility of extension.

  Further benets at the LMU:

• Easily accessible by public transport
• Company pension scheme
• Capital-forming benets
• Compatibility of family and career
• Mobile working

  • Flexible working hours

• Childcare support (e.g. offers for vacation and emergency care)
• Further education and training program at all career levels
• Participation in symposia and conferences
• Health promotion offers
• Theater and culture: special events, discounts and vouchers
• Mobility: discount on public transport (Job-Tickets), charging stations for electric cars and discounted membership of Share Now (car sharing).

People with disabilities who are equally as qualied as other applicants will receive preferential treatment.

Contact:

Please send your complete application (CV, certicates, list of publications, letter of motivation and two references/reference letters) by e-mail (single pdf le not exceeding 10MB) to Prof. Dr. Katia Parodi by December 31st, 2024 at the latest: sekretariat.parodi@physik.uni-muenchen.de

Prof. Dr. Katia Parodi
Holder of the Chair of Experimental Physics – Medical Physics Ludwig-Maximilians-Universität München
Am Coulombwall 1
85748 Garching
phone: +49 89 28 91 40 85

References

[1] K. Parodi and W. Assmann 2015 Mod. Phys. Lett. A 30 1540025 [2] S. Lehrack et al 2017 Phys. Med. Biol. 62 L20
[3] J. Lascaud et al 2021 Sci. Rep., 11(1), 2725

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